The hidden hormone behind insulin resistance nobody talks about

Hello everybody. Welcome to Tuesday night. Today we are talking about a

night. Today we are talking about a hormone that no doctor talks about, including me. In fact, the only place

including me. In fact, the only place that I think I've ever lectured about this hormone was to med students who were required to learn about it. And

every med student across the country used the same picture and textbook to say, "Hey, this mouse, this really fat one, is genetically designed to have no

leptin." that leptin makes is is a

leptin." that leptin makes is is a diabolical hormone that is the core root behind metabolic disease. And when you

have no leptin, they get this fat. But

when they have an excessive amount of fat of leptin, they also get this fat.

If you really want to understand why your insulin resistance is causing you to not be able to lose weight, this is what we will cover on the video tonight.

If you're looking for the I don't know, three quick steps to reverse insulin resist, I have a hundred of those. Go

look at them. But this is for the nitty-gritty, for the people who want to dive deep and understand why why does the weight not come off. Tonight, we

will learn why leptin is the most important hormone that nobody talks about. You're going to learn why it's

about. You're going to learn why it's important, why no one talks about it, and what I'm going to do to uh what I do for patients to reverse it. All right,

welcome to the chat. Tonight we have uh a great uh show, but also some numbers to share with you here that I have a pretty good job on my fast. I think I

started it I'm at 61 hours right now and I have a glucose of 68, a ketone of of

uh 4.1 and um I am in a good state of hormesis. I do want to talk about

hormesis. I do want to talk about there's a big announcement that I have that some of you may have suffered from.

So, stick around for the announcement later on in the video. And I um also will be watching your questions. Uh if

you've got questions, type them into the chat. My team sorts them for the ones

chat. My team sorts them for the ones that are most relevant to the topic we're covering. And that's how we uh

we're covering. And that's how we uh that's how we educate. That's how I answer questions. So, join me on this uh

answer questions. So, join me on this uh adventure on teaching about uh about leptin. Um the uh the hormone that

leptin. Um the uh the hormone that nobody talks about, including me. Here

we go. Let's get over to the slides and start with our big fat mouse. Yes, this

is what leptin looks like when it's not working. Uh many times I've covered

working. Uh many times I've covered several of the hormones that are um that are uh peptide y leptin's right there, GLP1, gip, choleiccytoine, and all of

these hormones are part of how you feel satiety. Uh we know that if you if

satiety. Uh we know that if you if you're trying to fight that, ghrelin, insulin, and cortisol are the opposite.

Uh if you've missed the the the factchecking that leptin uh is one of the many things that uh talks to your brain uh we're going to cover that too.

Um what we really want you to start with is the two biggest headlines which is that leptin tells your brain that you had enough to eat and that it tells you

how to help regulate your fat storage.

So, I'm gonna start with uh the comment that uh fat bodies have their brains hijacked from leptin. Um I used to teach

the the first step I would tell med students was leptin is the lean tin man.

Uh and that's because when their leptin was working well, they just couldn't put on weight. They could eat all they

on weight. They could eat all they wanted and just couldn't put on weight.

And I like to use this story to teach how hidden leptin is in the world of weight gain and weight loss. So I'm the mom of three boys. They are all uh north

of 18 now. But when they were in their younger teen years, one of the favorite things they love to do was to go to Brazilian Grill for their birthday. They

would count down to it. And if you've never been to this place, it's like every boy's fantasy, maybe that they walk around with meat on a stick and they bring it to you and they slice off

this fat, salty, juicy meat. Uh, and oh, my kids would just pig out at this place and they would count down to it. But

there were several uh several visits in a row where this strange thing happened to them. And as they were driving home,

to them. And as they were driving home, you could hear them talk about how this this weird spell came over them that they couldn't eat anymore. And so they were headed to the the next birthday thing and they had this strategy that

whatever spell comes over them when they're at the Brazilian grill, they were going to outsmart at this time by eating as fast as possible before whatever hypnotic thing takes over their

brain where they just cannot eat another bite. And of course, what they're

bite. And of course, what they're fighting against is they were lean and healthy, and their leptin worked well.

That leptin did a great job of screaming at their brain, "Hey, you're full." To

the point that it doesn't matter that they had counted down for two weeks to go to this restaurant. They could not fight what their hormones were telling their brain to do, which is you're done.

You're done. You're done. And under that control of the Brazilian grill, the leptin in their in their fat cells, which comes from their fat cells, went to their brain and said, "Uh-uh, I am

going to outsmart you. Uh, this high amount of leptin that's in your body right now, it's like a force field that won't let food go in your mouth." But

the same problem with their high leptin is also what happens when patients are obese. And when those patients are

obese. And when those patients are obese, their fat cells have grown and grown and grown and uh the leptin

doesn't uh allow their brains to u to to they can't sense it. Let me show you a slide that it does a pretty good job of just walking you through this. Uh here

we go. So you have this one, but here's your stomach. You put a bunch of steak

your stomach. You put a bunch of steak in that stomach and you're let that that sends a message to your brain that you're full. that the leptin inside your

you're full. that the leptin inside your fat cells will teach that brain that I don't care how strong you think you are.

You cannot outsmart what I'm doing. And

in healthy people, that just goes up and down very rapidly. It is a pulsatile hormone like most hormones are. And you

win. You're not you're not going to be able to out eat leptin. But when you start to grow a bunch of fat cells and those fat cells are oversized and now

you're in a season where the leptin has just hijacked your brain, in that case, I don't care how much uh you tell yourself you're not going to eat. When

you don't have this hormone helping you, you you become obese. You become obese.

The fat cells just keep growing and growing and growing. So, in this um this picture that we would use for the med students, uh we would have them say, "Yeah, this is what it looks like when

we genetically engineer you to not make any leptin." And you say, "Well, I want

any leptin." And you say, "Well, I want leptin, then I want to be lean." But as soon as that leptin would get high, you would also have the same fat rat. You

would have a same obese rat. It's much

like when you're looking at um the um uh like the first time you have caffeine uh or the first time you have nicotine or alcohol, your body says, "Hey, um uh

this new chemical is is exciting and you get a rush from it or a buzz from it.

But if you constantly put that in your system there, it doesn't have the same effect." So, leptin has this this like

effect." So, leptin has this this like this backwards uh uh science that says when it's too high, you're fat and when

it's too low, you're fat. Um here, let me use a different story to teach the same effect. So, about uh probably 3

same effect. So, about uh probably 3 weeks ago now, there's this woman who has been obese, like 75 lbs overweight

uh since she was 12. She's now 25 years old, and she's done. She says, "I want to be lean. I don't want to be on all the other hormones, but I'm going to do this. Um, uh, you know, I'm in control

this. Um, uh, you know, I'm in control of what I eat. I can be disciplined."

And she signed up for something really brave, which was 100 days of like this intensity challenge, much like a CrossFit workout. She was going to do a

CrossFit workout. She was going to do a 100 days in a row. So, she tells me this a while ago, and now it's at the end of the 100 days. I don't think she's quite at 100 right now, but she has a

25-year-old girl. She is not lying to me

25-year-old girl. She is not lying to me when she says that I don't feel like I'm overeing, but she has is 90 plus days into this experiment where she's been doing

CrossFit and by golly, she is definitely stronger, but she has not lost any fat.

She has not lost the weight. She has

gained muscle, but she has not lost weight. And she is just devastated. She

weight. And she is just devastated. She

she knows that the fat around her middle, the fat on her back, the fat in her arms shouldn't be there. And at 25 years old, she is at a severe risk for

having one of the root causes of long-term metabolic disease at 25 years old. And of course, what she's missing

old. And of course, what she's missing is the same thing that my boys couldn't see is that she can't lose this weight when that leptin is super high, when those fat cells have been around for

ever and ever and ever. And when when I look at um you know the ways to help her, we'll get to that in a minute. Uh

let me let me show you the slides that say what is happening deep inside her cells at 25 years old. And I know this and um well from years of seeing

patients, but let me let me show you why I know this. Go to this one. All right.

So there's our fat rat. And when you have no leptin, you get too much body fat. But when you also have um too much

fat. But when you also have um too much leptin, the fat cells grow and you become a fat rat. I mean the same thing, you get excessive amounts of fat and you cannot get it off. It is it is why

you'll hear people say but but I have I've been told that I have a set point.

I can't undo it. And indeed when their fat cells have overgrown, the amount of hormone that's coming from their fat cells is uh a steadystate elevated

hormonal level. And boy, it does really

hormonal level. And boy, it does really block that brain's ability to feel um uh to feel the pressure of eating. Um we'll

stop eating when it uh uh we're full, stop eating. That's uh what it usually

stop eating. That's uh what it usually says, but as it's excessive, you can't hear it. The brain can't hear it. So

hear it. The brain can't hear it. So

even though she thinks she's not eating, um you know, that metabolic churn of having those muscles exercised is what she's really suffering from. So she uh

puts uh that leptin in, her brain ignores it. And this at a young age, at

ignores it. And this at a young age, at 25 years old is what she is, you know, definitely um um um at a struggle with

in order to reverse um well, she won't be able to reverse the problems until she fixes this leptin resistance. All

right, so let we've got we've covered one part of this. Yes, your bodies uh get hijacked by high fat. But the second reason why um that that I want to cover

is by this part of the video, you're probably thinking, I don't know, that I wear a tin foil hat or something because if this dang hormone is so important, why why is nobody talking about why have

I never talked about it in 10 years plus of making videos for you guys? Why do I just avoid leptin? Why do I only teach the med students about it? And for

starters, it's it's almost like uh no one talks about this because it's too much for the exam room when this 25 year old woman

comes in and says, "Um, all right, I did what y'all said was right. I did this exercise. I'm sweating my butt off. I've

exercise. I'm sweating my butt off. I've

got muscle mass. I can do, you know, a pull-up for the first time in my life, but my fat mass is still excessive." Uh

and and now I'm trying to I mean instantly I know the problem she has is leptin but it's not like a typical typical thing that I find in patients

where I can go measure it. I mean if I measure it and it's high but she's unhealthy I know that that high leptin is causing her leptin resistance,

insulin resistance, and it's causing her fat cells to be locked and not be able to lose weight. But if she's lean and her leptin is high, well then I know

she's full. Okay. So this high hormone

she's full. Okay. So this high hormone has two opposite messages depending on the other biochemistry that's going on inside her system. And as she comes in,

I mean, I'm, you know, 15 minutes into this video explaining things to you with some pretty nice slides and um uh you know, some visuals. Uh, and I still

haven't got to the part where that shows you exactly what's the naughtiest thing happening in her body. And uh, right now she walks in and says, "I guess I'm just

supposed to be big boned." And I'm like, "No." Um, however, uh, the other reason

"No." Um, however, uh, the other reason that I wouldn't talk about it with a patient is you can try to explain all this to them. She does not want to hear about a mythical hormone that's in the

background of things that's causing all the problems and making her fat cells uh, high. And um, again, one of the one

uh, high. And um, again, one of the one of the things I used to teach in med school was the only way that we know to reverse this is a time machine. I mean,

every person that we made lose weight who had already had lept leptin resistance, well, they gained it right back. And you're like, well, that's

back. And you're like, well, that's awful. So, the only option once you've

awful. So, the only option once you've been obese for that long is to is what I mean that like nobody wants to say that to a patient. Nobody wants to talk about that. And what's the saddest part is

that. And what's the saddest part is that the metabolic disease that she's creating isn't just that she has insulin resistance. You've heard me talk about

resistance. You've heard me talk about insulin resistance over and over again.

um that leptin resistance does lead to insulin resistance. Um uh and that

insulin resistance. Um uh and that insulin resistance many of you know is uh you know that blood sugar is going to get higher. Those um I mean she's 25 so

get higher. Those um I mean she's 25 so she probably doesn't see the rise in blood sugar yet but it's taking buckets of insulin to keep that blood sugar

down. And as that insulin is high um the

down. And as that insulin is high um the leptin is also blocking what what the insulin does in her body. So it's like it perpetuates the insulin resistance

and again um nobody wants to talk about it because the antidote is awful. So

yeah, you guys know the stories of blocked insulin uh leads to this high blood sugar leads to you know insulin resistance and if you do that long enough you're going to have diabetes.

But what I think what is even a more important layer that's happening deep inside the human body and in actually in every mammal is when leptin is at that

high steady state, it causes the insulin receptor and this LDL receptor to do something really naughty. Okay, this is a a a slide that I've shown many times before. You're looking at a liver. Those

before. You're looking at a liver. Those

little catcher mitts on the liver are supposed to be the the receptors on of paddocytes that recycle lipoproteins.

And as your body circulates these little droplets of fat called lipoproteins, this is where your bad cholesterol, good cholesterol, VLDLDL cholesterol all come from. they they land in one of those

from. they they land in one of those catchers mits in a healthy liver and then they get recycled that as soon as they're in that catcher mitt you will see them go up into the liver and this

keeps the residency time of that LP that uh uh lipoprotein very short that's what healthy people do when you have a liver

that looks like this one that's full of triglycerides full of fat and now those catchers mits for LDL receptors well you have a different equation going on you'll You'll notice that in this case,

all of them are the same size. They're

only focusing on recycling the smallest of LDLs. And if you'll notice the color

of LDLs. And if you'll notice the color coding, which is really subtle on this slide, the color coding um oh, first of all, leptin causes you to also

downregulate uh those catchers so you don't have as many. Uh but it doesn't change what's circulating in your blood.

When you look at the blue light lipoproteins versus the purple ones, the purple ones have been circulating around in the blood longer, they're oxidized and they're very dangerous. But in this

case, because of that excessive amount of of leptin, you're now growing cardiovascular disease. You're making a

cardiovascular disease. You're making a heart attack in the future. You're

causing the stroke that's going to happen in the future. Why? Because you

are not recycling these LDL particles.

And this is where the uh you know the the science is right and when those particles hang out in your blood too long they do cause heart disease. They

do cause brain damage. So the answer is don't let them hang out there that long.

But if you're this 25-year-old woman, are you saying the only option I have to offer her is time travel? Is that really what we're going to tell her? I mean

insulin at this high of a level uh is a consequence of the leptin and so is the

um the the um the body's adaptation of sequestering those lipoproteins outside of the artery walls and making atherosclerosis. All right, so here we

atherosclerosis. All right, so here we have this again. Your the high leptin causes metabolic disease because of its leptin resistance. It's blocking that

leptin resistance. It's blocking that insulin and it's shutting down those LDL receptors. super important for the

receptors. super important for the disease state and the disease growth. Uh

I mean growing of disease for um for the the um patient. All right. So I'm going to

um patient. All right. So I'm going to pause. We're going to get to the next

pause. We're going to get to the next part which is how do I fix it? What is

the way that you can undo this? Because

being in this space this long is not um is not easy. Uh but I will tell you uh that I I regret knowing regret thinking that the only way you can undo this was

time travel. All right. So before we do

time travel. All right. So before we do that, we have an announcement quick to make.

And one of the announcements is something that I wish I uh didn't have to tell you. Let me go over to my website. We had a you might have known

website. We had a you might have known last week was Prime Day or Prime. Yeah.

Prime Day. called Prime Day in uh on the um on Amazon. And thanks to all of you that bought uh um packages on Prime Day.

But I will tell you that um I am a great doctor. Manufacturing still continues to

doctor. Manufacturing still continues to um baffle me in some ways. And we have had some complaints about what happens when the BHB coming from Amazon is

getting to your house. And I will tell you that I can't control the heat. But I

do take full responsibility for being one of the highest ketone per scoop on the market. And the downside to that is

the market. And the downside to that is this is a problem 2 years in the making cuz the shelf life of this is still 6 months uh away. But uh that heatwave

that came through hardened a bunch of our BHB tubs. Now, we've had it safety tested. It is not a safety problem. Um

tested. It is not a safety problem. Um

it is still just as potent as ever. I

actually had one of my teammates say she took it, put it in a blender, grounded it all back up, and put it back in the bottle, and it's it stayed uh nice and fluffy. Uh we have stopped shipping it

fluffy. Uh we have stopped shipping it out of our of our um of our um uh warehouse in Texas because the heat

there is just the same problem that the Amazon trucks were having. And I I again, this is a problem two years in the making. We thought this was solved.

the making. We thought this was solved.

But if you did get one of the containers, let me remind you there's a few pro few problems with sending it back. Number one,

back. Number one, um I'm out. I mean, I did um you know, they're either I I might have a fire sale for raspberry lemonade. That's

hard. Uh but uh right now I I the next batch of raspberry lemonade. I knew this was coming. That's why I made an extra

was coming. That's why I made an extra big batch in November of last year. Um

is that the prices are going up that these are this is real. It's happening

to every company, but um I don't have any on hand except for the stuff that's hard, and I do not have um uh I mean, I'm in line to get product made, but I'm waiting. So, there's nothing to refill

waiting. So, there's nothing to refill that with. Now, if you want the stuff

that with. Now, if you want the stuff that I'm drinking tonight, which is not as high as potency, but does not go bad, and it tastes just as good, and it's it's still better than most of the other

things that are on the market, but um it's not my super sexy raspberry lemonade. Um uh I'm I'm actually

lemonade. Um uh I'm I'm actually drinking it tonight for the first time in a while and I'm like, "Oh, that actually tastes pretty good." It's a It's the other flavors that are out there, which is cucumber, lemon, the

chocolate, uh Dutch chocolate, and the Mexican spice chocolate. So, those

flavors are still available, and they they are in sachets, so they do not clump. And that's great. But, um the

clump. And that's great. But, um the raspberry lemonade, if you did get a batch, I would just please be nice to me. Just put it in a blender. It's not

me. Just put it in a blender. It's not

going to hurt you. uh it still tastes as good. Um it's a it's a consequence of

good. Um it's a it's a consequence of being too high of BHB uh for the heat.

And I don't know, lesson learned. I

would like to say that, but I keep thinking that I don't want to lower the amount of RA uh ketones in the formula.

I have, you know, patients that depend on that delivery. And I I'm just going to say it's very expensive if you try to spend send it back. Amazon is barely I mean the reason I'm raising prices and

I'm probably the last one in the industry to do that is that I don't like doing that and um I would ask you to just blend it up and please don't send it back. Uh and if you have anybody

it back. Uh and if you have anybody that's complaining about it, help me educate them in the nicest way possible um that this is happening. So um stay tuned. Um I know that several of you are

tuned. Um I know that several of you are t tuning in today also for some announcements. Those announcements will

announcements. Those announcements will start next week when it comes to the 21 uh day metabolic kick. Again, that's our class where I teach you how to do the things that I will be teaching this

25-year-old how to do. Uh there is no better way to learn this than in a real live conversation that is not pre-recorded, but is a live interactive course that we do twice a year. I'm

super proud of it. It's my favorite thing that I do every year. It's called

the 21-day metabolic kick, and we only take 200 students. uh the people watching the show this far into the show will get a um a sneak peek. Uh you'll

get a you'll get something. So, tune in next week. Um and then we will send

next week. Um and then we will send emails out to folks um that are on our email list. Um that is a a big part of

email list. Um that is a a big part of how we we that's the way we advertise anymore. We don't we sell out. So, I'm

anymore. We don't we sell out. So, I'm

not worried about that, but I'm trying to get it to the people who need it the most. Um, in the past we've used uh an

most. Um, in the past we've used uh an extension program through the clinic that uh could offer um GLP1s to anybody whose metabolism isn't responding the way we think it should. Uh and that's

been just wildly successful. I'm super

excited to share that those updates with you over the next few weeks, too. All

right, let's get back to uh the final part of what we are talking about here.

So, yes, we've covered why um why your uh why it's important uh why nobody talks about it. Nobody likes to tell somebody that they need a time machine and that if it's high it's bad and if

it's low it's bad. Uh it's very difficult to talk about. Um but uh in the way that you uh try to reverse this

um is the only enemy to a um the only enemy to a high leptin state, a statically elevated leptin state is a

ketone in circulation. that your

hormones, your chemistry set it cannot be fought with discipline. Uh that this gal, this 25year-old who is God bless her heart, she is pushing so hard. Uh

it's not going to reverse unless she uses she has to outsmart my hormone needs to outsmart her hormone. And you

must start with a ketogenic state. It's

why um you'll see the carnivore folks that will lose weight. And I'm all about carnivore people as long as they're hitting a ketogenic state several times throughout the week. Uh if they've been chronically obese, and the doctors say,

"You've got a set point. You're always

going to go back to that. You're never

going to lose it forever." That's not true. But you must reset this hormone.

true. But you must reset this hormone.

This hormone can't reset until you play the game that that is chemistry. I mean,

that is truly chemistry. All right,

let's go over these slides and say yes.

Um, you've got high leptin and when you have high leptin, uh, you have a brain that will ignore it. It is is a stat a stat a steady state, a static state. Uh,

that will cause that insulin resistance to happen. That will cause those LDL

to happen. That will cause those LDL receptors to shut down and not recycle your cholesterol. and you are making

your cholesterol. and you are making metabolic disease beyond beyond our prediction much sooner faster and more aggressive than we usually see when

leptin is is at a high static state you'll get high inflammation we used a knee here but I think of things like your uh homoyine will be elevated your C reactive protein will be elevated you'll

have a chronically elevated feritin these are all markers that your body is is has goo it's chronically inflamed and this is in part because that chronic that of that chronically elevated

leptin. So the risk of heart disease

leptin. So the risk of heart disease we've talked about. So when you add a ketogenic state um you now change several things. Um this breaks the

several things. Um this breaks the signal. This breaks I mean in part is

signal. This breaks I mean in part is you're lowering insulin by decreasing the amount of carbs. But even if you just say swallow a bunch of ketones and watch what happens. Uh this gal is doing

a lot of things right and she does eat better than she used to but she can't shrink these fat cells without the signal that comes from a ketogenic state. Now she's trying her hardest to

state. Now she's trying her hardest to get there but she has about you know 12 years of behavior that keeps her eating in a way that even even though she

recognizes it she needs a without the hormones to help her it's going to it's going to be really difficult. So leptin

does drop that and that leptin the brain starts to listen to that hunger and it regulates the hunger better. I think

that's one of my favorite things about the first week that they're in a state of ketosis is what happens to the way they see the world and the way I see into their eyes. um that uh that state

of high insulin state becomes much lower and although it's a pulsatile way down uh it is uh begins to work again and now you have LDL receptors that clear

cholesterol this is how you keep that fat circulating that keeps those sex hormones going that keep that fights c chronically elevated cortisol that uh repairs the brain repairs the other

injuries in the body and when I look at um the uh the clearing of that inflammatory process inside the arteries, it also is a process of

removing the inflammation caused by excessive leptin. Um when I look at uh

excessive leptin. Um when I look at uh the the places that I mean I've spent years trying to teach patients, I mean this woman comes into the exam room and

I want to tell her all of this background science, but there's no way she wants to hear any of this. that when

I look at the amount of time it takes me to a understand it, teach it to med students or teach it to colleagues, um, even then they're not going to want to tell their patients about it because it

really isn't fair that before I had a good grasp on what the ketogenic diet could do, the best I could offer this woman was a prescription pad for a time machine. That you are you're screwed.

machine. That you are you're screwed.

your your your fat cells are in a steady state of leptin production and there is no writing in the textbook that says how to undo it, how to get them backwards.

And this uh 25-year-old pushing every day for a 100 days is a perfect example to say it's not because she's not trying hard. It's because the hormones she's

hard. It's because the hormones she's using require a persistent repeated visit of keto of ketones. Even if this woman would just drink ketones, she would have lost some she would have

started the spark of emptying those fat cells. Uh but leptin resistance uh very

cells. Uh but leptin resistance uh very powerful in how it will hijack their brains, hijack their bodies, and um then lead to, you know, lead they give up,

they lose hope. All right, we're going to get to your questions here. I am

going to do something I haven't done in a few weeks, which is check my glucose and ketones. I'm gonna finish drinking

and ketones. I'm gonna finish drinking my um my BHB. Um, my fast started on Sunday and um I have a an adopted

Chinese daughter who uh is a um super fun gal to have in my life and she has perfected how to make uh sourdough bread. So, I couldn't help it. I don't

bread. So, I couldn't help it. I don't

know how to make sourdough bread. So,

she brought it over. I ate some. It was

really good on Sunday. And then I I just realized whenever I do that, my fast on Monday is a little harder when I've when I've say carb loaded. I don't do that on purpose, but uh if you're going to figure out how to make sourdough bread,

I'm going to I'm going to say thank you and I'm going to come back and ask for uh a slice or two. All right, let's get into your questions. Again, this is when

we answer those questions uh from you throughout the um throughout the um channel. So, folks bring these here and

channel. So, folks bring these here and my team helps me. Let's get a little smaller. Um helps me find the ones that

smaller. Um helps me find the ones that fit uh the topic. Go one more time.

Okay. My husband after four months of very highfat meal a day, my husband still feels like he is starving. Yeah.

So, is this a leptin thing? Uh Rachel,

I've seen this a lot of times and I will say you it is absolutely because of leptin. Uh I'm going to guess that he's

leptin. Uh I'm going to guess that he's been overweight for many years that his fat cells are stuck in a steady state of leptin and that his brain can't hear oh like what my kids were hearing that they're so full they can't eat another

bite. He hasn't been to that chapter in

bite. He hasn't been to that chapter in years. But if you're looking for the

years. But if you're looking for the antidote for how to get his leptin to first reset, I would contend that most of my insulin resistant patients or

leptin resistant patients when they go on a highfat uh ketogenic diet um at first they get a wave of ketones and those first few days can feel some

satiation that is almost oblivious to them. Uh again the ketones are flowing,

them. Uh again the ketones are flowing, their new diet is weird. uh sometimes

they still have that oily slick inside their mouth and on their teeth. So

appreciating what it feels like to feel full kind of is uh down on the list.

It's like number 15 on the list. But

once you get to the place where he's got used to the menu and he's, you know, hopefully finding joy in not overeating, but you need to outsmart his hormones. I

would be pulsing the ketones up which do a paradoxical reduction of that leptin.

And again, the best way to do this is, you know, I don't know, eat sardines for three days or do some of those goofy things or just swallow them, have ketones that burst up. And I would I would I mean, if it was my husband, I

don't like him grabbing at me. So, I

would say, "Nope, you need two doses a day for for 10 days." So, you'd have a dose in the morning and a dose at night.

And again, it will be uh, you know, a cucumber lemon or whatever. Uh, the

again, the raspberry lemonade has the highest potency. Pucker Up is second,

highest potency. Pucker Up is second, but it's really tart. If you're not used to sour, do not do not get this one. Um,

but it shoots those ketones up and they now now you're fighting a hormone with a hormone. Do you have to stay on it

hormone. Do you have to stay on it forever? No. Once you start to bring

forever? No. Once you start to bring that leptin down, you open up those fats. You begin to have something called

fats. You begin to have something called lipolyis, the production or the u the freeing of fatty acids. they they

circulate now to your body and they're able to be used as a source of fuel and it's powerful how that tipping point of 10 days of you know pulsing those

ketones twice a day and then then they're off to the races and now now they've now they've got a new season. Um

the other part of that is uh like this gal that's 25 and been over you know 70 pounds overweight for 12 years uh her ability to sense satiety is broken. like

I don't she doesn't do it normally anymore. It's partly because of leptin

anymore. It's partly because of leptin and teaching her what that feels like.

That's where the things like the stick of butter came from. That's where the sardine fast comes from. That full means something completely different when that hormone is working and you put a bunch

of fat uh with protein in. Uh and I know these lean women that are influencers, you know, come on and they'll say, "I eat so much I can't I can't eat anymore." And you're like, "Yeah, that's

anymore." And you're like, "Yeah, that's leptin talking." What happens? What do

leptin talking." What happens? What do

you do before that? And you got to pulse the ketones. So, there are other ways to

the ketones. So, there are other ways to do it, but the fastest, simplest way and the safest way is to just swallow the ketones twice a day for 10 days. U all

right, let's go to the next question.

Uh, thanks for pointing out the sound by by the way, everybody. Okay. Does taking

ketones three times a day for 3 weeks help to produce more ketones? I'm a

carnivore and low leptin uh and insulin.

Um, I'm on a carnivore diet and he needs to lower the leptin and lower the insulin. Yep. Just like I said before,

insulin. Yep. Just like I said before, that's exactly what I If you can do it three times a day, great. It they are expensive. I'm not trying to make light

expensive. I'm not trying to make light of that. Um it's why I try to put so

of that. Um it's why I try to put so much in a scoop. And if you are if you're tuning in over the next couple weeks and we do a fire sale off of our website. Um I don't know if that's what

website. Um I don't know if that's what we're going to do, but uh stay tuned.

The the ketones aren't bad. It's the um it's the uh mean that they're hard. I

need them in circulation. And the

fastest way to do that is either uh handfuls of MCT uh and that will do it as well. That keeps the ketones up for

as well. That keeps the ketones up for about eight hours. Um so one of the ways that I have for a protocol for folks with dementia is they swallow ketones while swallowing a handful of MCT. You

know, good four tablespoons of the oil or, you know, good 16 to 20 of those uh soft gels.

I'm going to check my numbers, but I want to drink this before I check my numbers. Hold on.

numbers. Hold on.

Okay. Um, so Caroline says, "Does leptin affect cravings?" So, uh, the only

affect cravings?" So, uh, the only craving I mean, it's it's like they only have the on button. So, they can crave for food. They just never get to feel

for food. They just never get to feel the satiation of food. that first slide that I showed at the beginning where it said these things make it go up and this is what makes satiety go down. Uh that

was your cortisol, your insulin, and I can't remember which one I put on that there. Um

there. Um ghrein. Yeah, thank you. Uh ghrein. It's

ghrein. Yeah, thank you. Uh ghrein. It's

it it gives you the hunger for it. So

when leptin's out of whack, it it doesn't fight any of those other hormones and um the cravings become your enemy. Uh so cravings are in part from

enemy. Uh so cravings are in part from the lack of a hormone that's helping you. Uh there are some behavioral

you. Uh there are some behavioral things, but I don't talk about those until you've been in a state of ketosis.

Get the hormones helping you, and then we can talk about some behaviors. All

right. Uh next question is, um oopsy daisy. I know what I need to do there. Let me go to here and push this

there. Let me go to here and push this here. Uh

here. Uh yeah, actually uh we've got a uh a couple of questions coming in. Hang

tight there. I do want I'm going to check my numbers and do one more thing.

Um, I I want to say a couple of special shoutouts for the I've had summer interns for the summer who've been doing some great things on improving our uh

our email response time and answering those questions in a way that really do uh offer uh the best value. If you do have questions and you're trying to get direct messaging from us, you're going

to see most of our attention goes into the uh the back and forth of our email.

Um, so if you've got things that you're saying, I posted a question and I don't have the answer yet. Uh, put that in our email uh hello@bosmd.com.

And the the folks on my team are really good about doing it. They do, uh, they make me look great. All right, I'm checking those numbers, uh, again at the

end. And, um, I will see if there's any

end. And, um, I will see if there's any more questions that have to do with uh, leptin and grein. If not, we'll call it a night. Let's see what that uh um here

a night. Let's see what that uh um here in Tampa, we are a few hours away from uh a hurricane that's supposed to fly over us. So yeah, my glucose is still

over us. So yeah, my glucose is still 67. Uh that was close to what it was at

67. Uh that was close to what it was at the beginning. And my ketones after that

the beginning. And my ketones after that after this uh um uh raspberry lemonade or u cucumber lemon or they read high. I don't know if

you can see that on that flasher there.

Yeah. So um I'll I'll use those just fine.

All right, I think that is the end of our thing. We are done a few minutes

our thing. We are done a few minutes early, but I just want to say thank you for the questions and thank you for uh all of you that helped me uh recycle that uh raspberry lemonade to anybody

who isn't going to send it back and crab about it. So, be nice. I'm a great

about it. So, be nice. I'm a great doctor. Manufacturing is still uh kind

doctor. Manufacturing is still uh kind of beating me up a little bit. So, I'll

keep doing it and you keep showing up.

See you next week, everybody.