The Science of Gratitude & How to Build a Gratitude Practice | Huberman Lab Essentials
By Andrew Huberman
Summary
## Key takeaways - **Gratitude practice is not what you think**: Common gratitude practices like simply listing things you're grateful for are far less impactful than engaging in story-based gratitude practices that focus on receiving thanks. [00:40], [14:30] - **Receiving gratitude is more potent than giving**: Studies show that the act of receiving gratitude, particularly through a story where someone is thanked wholeheartedly, activates beneficial neural circuits more robustly than expressing gratitude. [14:43], [25:55] - **Storytelling activates gratitude circuits**: Engaging with narratives about others receiving help or expressing thanks, especially when embedded in a larger story, powerfully activates the brain's pro-social and gratitude networks. [16:32], [18:02] - **Gratitude reduces anxiety and boosts motivation**: A regular gratitude practice can shift functional connectivity in emotion pathways, making anxiety and fear circuits less active while enhancing circuits for well-being and motivation. [26:26], [28:14] - **Gratitude practice lowers inflammation**: Practicing gratitude has been shown to rapidly reduce amygdala activation and decrease inflammatory markers like TNF alpha and IL6, contributing to better immune function. [29:44], [30:03] - **Build a potent gratitude practice**: Effective gratitude practice involves using a genuine story of receiving or observing thanks, supported by brief bullet points as cues, and focusing on the feeling for 1-5 minutes. [32:31], [33:36]
Topics Covered
- Gratitude permanently shifts your brain's pro-social circuits.
- Your brain's prefrontal cortex defines experience meaning.
- Does your gratitude practice actually work?
- Receiving gratitude (or observing it) is the most potent practice.
- Build a narrative-based gratitude practice for lasting change.
Full Transcript
Welcome to Huberman Lab Essentials,
where we revisit past episodes for the
most potent and actionable science-based
tools for mental health, physical
health, and performance.
I'm Andrew Huberman and I'm a professor
of neurobiology and opthalmology at
Stanford School of Medicine. Today we
are talking all about the science of
gratitude. There's now a wealth of data
showing that having an effective
gratitude practice can impact a huge
number of health variables, both mental
health and physical health, in positive
ways. However, in researching this
episode, I was completely surprised as
to what constitutes an effective
gratitude practice. I I think like many
of you would have thought that an
effective gratitude practice simply
involves writing down a few things or
many things that we're grateful for or
thinking about those or really making an
effort to summaticize or feel some of
the elements of gratitude while writing
out that list or thinking about that
list. It turns out that an effective
gratitude practice doesn't resemble that
at all. the neuroiming data, the
physiological data, looking at things
like inflammatory markers.
Other studies purely looking at the
psychology and the long and short-term
effects of an effective gratitude
practice point to a completely different
approach to using gratitude to
positively impact health metrics. There
are studies showing that performing a
gratitude practice twice or three times
or even just once a week can lead to a
pervasive a longlasting impact on
subjective well-being. People report
feeling happier, more meaning, joy, even
awe for their life experience simply in
response to adding a gratitude practice.
But there are additional benefits of a
gratitude practice. There are studies
showing that a regular gratitude
practice can provide resilience to
trauma in two ways. It can provide a
reframing and resilience to prior
traumatic experiences. So, buffering
people against the negative uh
physiological effects and psychological
effects of earlier trauma, but also
inoculating them in many ways to any
traumas that might arrive later in life.
The other thing that a gratitude
practice does is it's been shown to
benefit social relationships, but not
just for the relationship in which you
express gratitude. Right? So on the face
of it, you might think, okay, if I
express gratitude for somebody over and
over and over and over over and over,
then I'm going to feel better about that
person. And indeed, that is one effect
of a gratitude practice that's called a
pro-social or interocial gratitude
practice. But there are now several
studies, recent studies in good journals
pointing to the fact that a regular
gratitude practice can also enhance
one's social relationships across the
board in the workplace, at school, with
family, in romantic relationships, and
even one's relationship to themselves,
which is really what the subjective
feelings of well-being are. And for
those of you that are coming to this
conversation thinking gratitude
practice, oh that's kind of wishy-washy
or woo, it's going to involve, you know,
putting your hand on your heart and
feeling into all the amazing things that
you happen to have even when things are
really terrible. That's not where we're
going at all. So if you are of the
mindset that a gratitude practice is
kind of weak sauce, um, buckle up
because the data actually point to the
fact that a gratitude practice is a
very, very potent way in which you can
steer your mental and physical health in
positive directions. and that those
effects are very long lasting. Before we
dive into the tools and mechanisms and
scientific studies around gratitude, I'd
like to just set the framework for the
discussion. Gratitude is what we call a
pro-social behavior or a pro-social
mindset. Pro-social behaviors are
basically any behavior or mode of
thinking that allow us to be more
effective in interactions with other
people, including ourselves. Now,
pro-social is not just a name that we
give these different tools and practices
and mindsets. They're actually neural
circuits in the brain that are
specifically wired for pro-social
thoughts and behaviors. So, without
getting into too much detail just yet,
we will later. We have circuits in the
brain that are what we call appetitive.
They are designed to bring us closer to
things and to bring us into closer
relation to the details of that sensory
experience. Now, that could be a
delicious food that you're eating. It
could be interacting with a loved one.
It could be interacting with a friend or
anyone that you happen to like. It could
even be in relation to yourself. And the
neural circuits in the brain that are
associated with aversive or defensive
behaviors are actually antagonized,
meaning they are reduced when the
pro-social circuits are more active. So,
the framework here that I'd like to set
is that we have this kind of seessaw of
neural circuits in the brain. one set
that are pro-social and are designed to
bring us closer to others, including
ourselves, closer to certain sensory
experiences, right? Because a lot of
pro-social behaviors can also be geared
towards things like pets or food or
anything that we find we want to be
closer to and want more of. Whereas the
defensive circuits involve areas of the
brain, yes, such as areas that are
involved in fear, but also areas of the
brain and body that are literally
associated with freezing or with backing
up. So the way to think about gratitude
is it falls under this category of
pro-social behaviors which are designed
to bring us closer to different types of
things and to enhance the level of
detail that we extract from those
experiences. The key thing for today's
discussion is that gratitude turns out
to be one of the most potent wedges by
which we can insert our thinking and as
you'll also see our the physiology of
our body between these two circuits and
give a little more levity if you will to
the side of the seessaw that's
associated with positive pro-social
feelings. And if you keep imagining this
seessaw imagery, what's really beautiful
about gratitude practices is that if
they're performed repeatedly, and not
even that often, but repeatedly, then
one can actually shift their neural
circuits such that the seessaw that I'm
calling pro-social versus defensive
behaviors can actually start to tilt.
What this means is that we now know with
certainty that a regular gratitude
practice can shift the pro-social
circuit so that they dominate our
physiology and our mindset in ways that
can enhance many many aspects of our
physical and mental health by default.
So we don't always have to constantly be
in practice trying to be happy. Now I'd
like to talk about some of the
neurochemistry and neural circuits
associated with gratitude and pro-social
behaviors. Numerous times on this
podcast, I've talked about so-called
neurom modulators. For those of you that
might have forgotten or have never heard
of neuromodulators before,
neuromodulators are chemicals that are
released in the brain and body that
change the activity of other neural
circuits. They make certain brain areas
more likely to be active and other brain
areas less likely to be active. These
neurom modulators have names like
dopamine serotonin acetylcholine
epinephrine, and so on. The main neurom
modulators associated with gratitude and
pro-social behaviors tends to be
serotonin. Serotonin is released from a
very small collection of neurons in the
brain stem called the Rafé R a PH, the
Rafé nucleus, and a few other places in
the brain. And the Rafé neurons send
these little wires that we call axons
out to numerous places in the brain. and
they tend to increase the activity of
particular neural circuits that lend
themselves to more approach to
particular types of experiences. That
makes total sense if you think about it.
have a chemical that under certain
circumstances is released in the brain
that triggers the activity of neural
circuits that makes the organism you
more likely to stay in an interaction
with something or even lean in and seek
a more detailed interaction with that
person, place or thing. And two main
brain areas are activated by these
serotonic systems. And when people
experience something that makes them
feel gratitude and the amount of
activation scales with how intensely the
person experience the feeling of
gratitude. And those two areas have
particular names. You don't need to know
the names, but for those of you that
want to know, they are the anterior
singulate cortex and the medial
prefrontal cortex. And of course, these
brain areas are connected to a number of
other networks in the brain. In fact,
that's how they get you or others to
lean into certain exper experiences
because when these areas are active,
certain thought processes get invoked.
Those thought processes probably
resemble something like, hm, I'd like to
experience more of this or this feels
really good. And then they literally
feed onto your muscles via the neurons
making you happy to stay stationary. if
you're experiencing something you like
or to move closer to something that you
find attractive to you literally. Many
of you have probably heard of the medial
prefrontal cortex because this is the
area of the brain that is involved in
planning and in deep thinking and
evaluation of different types of
experiences past, present or future. And
the reason it can be involved in so many
different things and the reason it's
especially important for gratitude is
that medial prefrontal cortex sets
context. Okay? It sets context and it
literally defines the meaning of your
experience. How is it that medial
prefrontal cortex sets the context of
everything in your life? Well, it does
it the following way. You have a number
of circuits deeper in your brain that
simply create sensations or they allow
you, I should say, to perceive certain
sensations. Let's use the example of
cold exposure, something that we
sometimes talk about in this podcast for
other reasons.
If you were to deliberately place
yourself into an ice bath, it would be
uncomfortable. Even if you're adapted to
cold and so forth,
the discomfort is non-negotiable.
However, if you are doing it because you
want to or because you have knowledge
that there are particular health
benefits,
the medial prefrontal cortex can then
control areas of your deeper brain like
the hypothalamus to positively impact
the neurochemicals that are released
into your system. Your knowledge that
you are making the choice, that it's you
that's deciding to put yourself through
this discomfort has been shown to create
a very different and positive effect on
things like dopamine, on things like
anti-inflammatory markers uh in your
immune system, etc., compared to if
someone pushes you into an ice bath, or
if you are doing it because someone
insists that you do it and you really
really don't want to. So, there's a very
subtle distinction here. It's just as
it's just the distinction of motivation
and desire or lack of motivation and
being forced into something. If you take
a mouse for instance and it runs on a
running wheel, which mice really like to
do, there are many positive effects on
reducing blood pressure, improvements in
neurochemistry, etc. in that mouse.
However, if there's a mouse in the cage
right next to it that's trapped in the
running wheel and it has to run every
time the other mouse runs because the
wheels are linked. Well, then the second
mouse that's forced to do the exact same
running experiences negative shifts in
their overall health metrics. Blood
pressure goes up, stress hormones go up,
etc. because it's not actually making
the choice. Medial prefrontal cortex is
the knob. It is or the switch rather
that can take one experience and allow
us to frame it such that it creates
positive health effects and the exact
same experience framed as something we
don't want to do or that we are forced
to do can create negative health
effects. Now how exactly the neurons in
medial prefrontal cortex do that is
rather complicated and frankly not
completely understood. But it's somehow
able to adjust the activity of other
neural circuits that are purely
reflexive as we say in neuroscience like
really dumb neural circuits that are
just like switches and place a context
onto it. So gratitude is a mindset that
activates prefrontal cortex and in doing
so sets the context of your experience
such that you can derive tremendous
health benefits. Which leads us to the
question, what kind of gratitude
practice is going to accomplish this?
You can't simply lie to yourself. You
can't simply say, "Oh, well, every
experience is a learning experience or
um you know, a terrible thing happens.
Oh, good. I'm just going to say good."
And that your body will react as if it's
good for you. That's a myth. And
frankly, it's a myth that's fairly
pervasive in the self-help and
self-actualization literature. We can't
simply lie to ourselves or quote unquote
fake it until we make it. Neural
circuitry is very powerful and very
plastic. It can be modified and it's
very context dependent, but it's not
stupid. And when you lie to yourself
about whether or not an experience is
actually good for you or not, your brain
knows. So, what does an effective
gratitude practice look like? Well,
let's examine what an ineffective what a
poor gratitude practice looks like.
because therein lies some really
important information including the fact
that I and I think millions of other
people out there are doing it wrong.
Most gratitude practices that you see
online and that people talk about in
various talks and so forth involve
something like writing down or reciting
or thinking about five or 10 or three or
20 things that you're especially
grateful for and then really trying to
feel into some of those. really try and
think deeply about the emotions, the
sensations, the perceptions that are
associated with those particular people,
places, and things on your list.
Most studies actually point to the fact
that that style of gratitude practice is
not particularly effective in shifting
your neural circuitry, your
neurochemistry or your somatic
circuitry. the the circuits in your body
because you literally have organs and
neural circuits that are connected the
circuits of your brain and body toward
enhanced activation of prefrontal
cortex, enhanced activation of these
pro-social neural networks that we were
talking about earlier. Turns out that
the most potent form of gratitude
practice is not a gratitude practice
where you give gratitude or express
gratitude, but rather where you receive
gratitude, where you receive thanks. And
this to me was very surprising. There
are a number of studies about this. Now,
uh, one in particular that I think is
interesting is called prefrontal
activation while listening to a letter
of gratitude read aloud by a co-orker
face to face, a near study, NIR. I'll
explain what all this means. You now
know what the preffrontal activation
part is. This is activation of the
prefrontal cortex. The NER's NIS study,
that's just a technical term. So, in
this particular experiment, what they
did is they had co-workers write a
letter of gratitude, of thanks to
another co-orker, unbeknownst to the
other co-orker. And then they sat down
together and then they imaged brain
activity as this letter was being read
and as the letter was being heard,
received. And it showed very robust
effects on these prefrontal networks
that pointed to the fact that receiving
gratitude is actually much more potent
in terms of the positive shifts that it
can create than giving gratitude. For
many people who are want to experience
the positive effects of gratitude, uh
you it's probably not um the most uh
advantageous approach to just sit around
waiting hoping that someone's going to
deliver uh all these uh letters or words
of gratitude. How is it that you can
create that sense of receiving gratitude
for yourself and thereby derive the
effects of gratitude as outlined in this
particular study? And there we go to the
important work of the great Antonio
Damasio who explored these neurooralates
of gratitude to define the areas of the
brain that are associated with
pro-social behaviors like the prefrontal
cortex. What they did was interesting.
Rather than have people express
gratitude, they had the subjects go into
the scanner. So their brains are being
imaged and they watched narratives,
stories about other people experiencing
positive things in their life. And and
in this case, this was these uh were
powerful stories. These were stories
about um survivors of genocide. So
that's what they're they're watching.
The subjects were were subjects that
were um not survivors of genocide. So
they were watching these videotapes of
people that had survived genocide and
had people help them along the way as
part of their story of survival either
psychological and or obviously there
they survived long enough to make the
videos so or physical survival. So
within these stories there was uh there
was a conveyance of a lot of struggle.
These people talked about the the
horrible situations they were in, but
also small but highly significant
features of their history that had led
to their own feelings of gratitude. So
for instance um you know it says a woman
at the im this is literally from the
scientific paper um you know somebody
had been sick for weeks. So the woman's
describing how she'd been sick sick for
weeks and then another prisoner who was
a doctor finds a particular medicine
somehow. it doesn't describe how and
literally saves her life. So these sorts
of stories now just hearing this in the
context of nothing but a scientific
paper in discussion. These probably
don't aren't that impactful. What's
really important about this study and is
really important for all of us to know
is that these stories of other people
receiving things that were powerful for
them in their life trajectory is
embedded in story. And the human brain
uh especially is so oriented towards
story. We we have neural circuits that
like to link together past, present,
future, have different characters, um
protagonists and antagonists from the
time we're very young until the time
we're very old. Story is one of the
major ways that we organize information
in the brain. There there does seem to
be storytelling and and story listening
circuits in the brain. So, what's
important is not um simply that these
people survived genocide. That's
obviously important uh and and
wonderful, but it's not just that they
were helped along the way. It's that the
description of their help is embedded in
a larger story. So the human subject is
uh in this scientific study is watching
these powerful stories and the neural
circuits associated with pro-social
behaviors and with gratitude become
robustly active when they start to feel
some affiliation with the person telling
the story. So if you think about the
earlier study that receiving gratitude
is the most powerful way to activate
these circuits for gratitude.
The subjects in this study in many ways
are receiving a sense of gratitude
but through the narrative of one of
these other subjects which I find
fascinating. You know, I would have
thought a great gratitude practice would
be sit down and list out all the things
you're grateful for. That just seems so
logical to me. But it turns out that
these neural circuits don't work that
way. that to really activate these
circuits for gratitude and the serotonin
and probably the oxytocin system as well
and the prefrontal networks, one has to
powerfully associate with the idea of
receiving help. So let's just take a
moment and start to think about how we
are going to build out the ultimate
gratitude practice meaning the most
effective gratitude practice for us to
do because of all the many positive
effects that an effective gratitude
practice can have if it's the proper
one.
It's very clear that receiving gratitude
is powerful, but it's also very clear
that waiting around to receive that
gratitude is an impractical approach.
What we know for sure is that there has
to be a real experience of somebody
else's experience and that the best way
to do that is story. So, in thinking
about how to build out an effective
gratitude practice, it's very
worthwhile, I believe, to find someone's
narrative that's powerful for you. In
many ways, to think about this is it's
got to be a story that inspires you
because of the, for lack of a better
phrase, the beauty of the human spirit
or the ability of humans to help other
humans. And I find this remarkable
because what this really means is that
the circuits for gratitude are such that
we can exchange
gratitude. We can actually observe
someone else getting help, someone else
giving help. And that observation of our
species doing that for one another
allows us to experience the feeling of a
genuine chemical and neural circuit
activation lift, if you will. very very
different than simply writing out the
things that you're thankful for, right?
And so, how would you do this? Well,
people digest story in a number of
different ways. People watch movies,
people uh listen to podcasts, people
read books. There are tremendous number
of stories out there. It's clear that an
effective gratitude practice has to be
repeated from time to time. So what I
would not suggest is that we build a
protocol in which you're constantly
foraging for inspirational stories over
and over again. Rather, the most
effective protocol or tool is going to
be
either to think into, and you could
write this out if you like, but think
into when somebody was thankful for
something that you did and really start
to think about how you felt in receiving
that gratitude or and or I should say
imagining or thinking about deeply the
emotional experience of somebody else
receiving help. I want to emphasize that
the story that you select does not have
to have any semblance to your own life
experience. It's just about what happens
to move you. And so the way that one
could do this is to find a story that's
particularly meaningful for you. And
then to just take some short notes,
bullet point notes, just list out for
instance, you know, what the struggle
was,
what the help was, and something about
how that impacts you emotionally. you've
written down um a few notes about what
that story is just to remind you um and
then you read those out and you think
into the richness of that experience
that receiving of gratitude. Now this
could be done literally for one minute
or 2 minutes or 3 minutes. This is not
an extensively long practice. Now if you
have an experience of receiving
gratitude or a story that's very potent
for you, it becomes a sort of shortcut
into the gratitude network. these
pro-social networks, meaning the
activation of these circuits becomes
almost instantaneous. And that's very
different than a lot of other practices
out there. Now, there's another very
clear and positive effect of using this
narrative or storybased approach to a
gratitude practice and that's what story
does for our physiology.
What this means for your gratitude
practice is that having a story that you
return to over and over again, even if
it's not the entire story, you're just
using the shorthand bullet point uh
version of your story, will create a
perceptible and real shift in your
heartbeat and in your breathing. And
actually, that's been demonstrated over
and over now that an effective gratitude
practice is one that can rapidly shift
not just the activation of these
circuits in your brain for pro-social
behaviors, but also
activation of particular circuits in
your heart and in your lungs and the
other organs of your body such that you
can get into a reproducible state of
gratitude each time. The key thing is
that you want to use the same story,
even if it's if it's your own experience
or somebody else's, and keep coming back
to it over and over again. That makes it
a very potent tool that you can get a
tremendous amount of benefit from with
even as short as 60 seconds of practice.
Earlier, I talked about how you can't
lie to yourself and say, you know, I'm
so grateful for this thing that I
actually hate. There's a really
interesting study published in
scientific reports which is a nature
research journal. Uh the title of it is
neural responses to intention and
benefit appraisal are critical in
distinguishing gratitude and joy. It's a
somewhat complicated study. So I'm just
going to hit on some of the high points
but basically what they did is they use
functional magnetic resonance imaging so
they could look at brain circuitry
activation with very high precision. And
they had people receiving money in this
in the context of this uh experiment and
they had some knowledge as to whether or
not the money that they were receiving
was given to them wholeheartedly or
reluctantly. They looked at whether or
not the sense of gratitude scaled with
the amount of money received
andor the intention of the benefactor.
whether or not the person giving the
money was doing it wholeheartedly or
reluctantly. And what's remarkable is
that while the amount of money given was
a strong component in whether or not
somebody felt grat that they had
received gratitude, which makes sense.
You know, the amount of money is is some
some metric of whether or not uh
somebody feels uh thanked.
The stronger variable, the bigger impact
came from whether or not the person
giving the money was giving it with a
wholehearted intention and not a
reluctant intention. This tells us um
many things that extend way beyond
gratitude practices, which is that
genuine thanks are what count. So this
constrains our gratitude practices
somewhat, but I think in an interesting
and important way. You can't tell
yourself that an experience was great or
that um you know I got a lot of money
and therefore it justified it uh even
though you know I think that they gave
it to me reluctantly or my boss hates me
but they gave me a raise and that tells
us that if if we are the giver that we
better be giving wholeheartedly or we
are undermining the sense of gratitude
that someone is going to receive from
us. So, we are gradually building up the
ultimate gratitude practice based on the
variety of scientific literature that's
out there. And I know that many people
are probably interested in developing a
gratitude practice that has long
lasting, maybe even permanent positive
effects on their neural circuitry. So,
with that in mind, I want to turn our
attention to a really interesting study.
It's entitled Effects of Gratitude
Meditation on neural network functional
connectivity and brain heart coupling.
And to make a long story short and a lot
simpler than that title, repeated
gratitude practice changes the way that
your brain circuits work. And it also
changes the way in which your heart and
your brain interact. You're familiar
with the fact that your brain controls
your heart because you could be stressed
about something that's perceived with
your brain and then your heart rate will
speed up. You're probably also familiar
with the fact that if your heart rate
speeds up for some reason or no reason,
you probably think, well, what's making
my heart rate speed up? And that's
because they the brain and the heart are
reciprocally in innervated as we say.
They're talking to one another in both
directions. It's a two-way highway. This
study looked at changes in so-called
functional connectivity within the brain
and between the brain and the heart in
response to gratitude practices. To make
a long story short, what they found is
that a repeated gratitude practice could
change the resting state functional
connectivity in emotion and motivation
related brain regions. If I haven't
mentioned a strong enough incentive for
doing a regular gratitude practice until
now, this is definitely the one to pay
attention to because what they found was
a regular gratitude practice
could shift the functional connectivity
of emotion pathways in ways that made
anxiety and fear circuits less likely to
be active and circuits for feelings of
well-being, but also motivation to be
much more active. I find that remarkable
and important because a number of people
struggle with issues of motivation. A
lot of people who are highly motivated
also have issues with anxiety and fear.
And so this study really points to the
fact that it's a twofer. If you have a
good gratitude practice and you repeat
it regularly, you reduce the fear
anxiety circuits. you increase the
efficacy of the positive emotion
feel-good circuits and the circuits
associated with motivation and pursuit
are actually enhanced as well. Thus far,
we've mainly talked about the effects of
gratitude on neural circuit activation
and changes. a little bit about some of
the changes that are happening in terms
of the body heart rate and breathing and
so forth. But we haven't talked a lot
yet about the changes in health metrics
in things like inflammation or
reductions in inflammation and immunity
and things of that sort. So with that in
mind, I'd like to describe the results
of a really interesting recent study
that was published in the journal Brain
Behavior and Immunity. This was
published 2021. And the title of this of
the study is exploring neural mechanisms
of the health benefits of gratitude in
women a randomized control trial. The
first author is HLlett. And basically
what this paper showed was that
women who had a regular gratitude
practice of the sort that we've been
talking about up until now showed
reductions in amygdala activity, a brain
area associated with threat detection, a
intimate part of the fear network in the
brain. So reductions in amydala
activation and large reductions in the
production of something called TNF alpha
tumor necrosis factor alpha and IL6
interlucan 6. Now if you happen to have
listened to the episode that I did on
activating your immune system and immune
function you heard about TNF alpha and
IL6. TNF alpha and IL6 are inflammatory
cytoines. These are chemicals that exist
in your body and that are released from
cells when there is damage or kind of a
systemic stress when your system is in
duress. And in the short term, they can
be beneficial. They can call in signals
for wound healing and repair of cells
etc. But you don't want TNF alpha and
IL6 levels to be too high and you don't
want those levels to be up for too long.
And so this study is really nice because
they showed significant effects in
reducing TNF alpha and IL6 in response
to a gratitude practice. And another
interesting aspect of this study is that
the reductions in amygdala activation
and the reductions in TNF alpha and IL6
were very rapid. They occurred almost
immediately after the gratitude practice
was completed. And even though that
study was performed exclusively on
female subjects, based on the biology
and circuitry of the amygdala and the
biology of TNF alpha and IL6 performing
this inflammatory role in both men and
women, I don't see any reason why the
results of that study wouldn't pertain
to both men and women. I'd like to just
highlight the key elements of the most
effective, at least to my knowledge,
gratitude practice. First of all, that
practice has to be grounded in a
narrative, meaning a story. You don't
have to recite or hear that story every
single time you do the gratitude
practice, but you have to know what that
story was and what the gratitude
practice references back to. Second of
all, that story can be one of you
receiving genuine thanks. And the key
elements there are that you are the one
receiving the thanks, the gratitude, and
that it's being given to you genuinely,
wholeheartedly.
Or it can be a story of you observing
someone else receiving thanks or
expressing thanks. And that has to be a
genuine interaction as well, both
between the giver and the receiver.
So those are the first three elements.
What I recommend would be after you've
established the story that you want to
use for your gratitude practice that you
write down three or four simple bullet
points that can serve as salient
reminders of that story for you. It will
serve as kind of a cue for that story
without having to listen to or uh talk
out the entire story. I would recommend
writing down something about the state
that you or the other person were in
before they received the gratitude. the
state that you were in or that the
person was in after they received the
gratitude and any other elements that
lend some sort of emotional weight or
tone to the story. This could be three
pages of text if you like or it could
just be a couple bullet points. I don't
think it really matters. The important
thing is that it's embedded in your
memory and that it's really associated
with this genuine exchange of thanks and
the receival of thanks. I think those
are the key elements. And then it's very
simple. The entire practice involves
reading off these bullet points as a cue
to your nervous system of the sense of
gratitude and then for about 1 minute
which is a trivial amount of time if you
really think about it or maybe two
minutes or if you're really ambitious up
to five minutes of just really feeling
into that genuine experience of having
received gratitude or observed someone
else receiving gratitude. So if we just
take a step back from this protocol and
compare it to what's typically out there
in the literature, which is, you know,
make a list of all the things you're
thankful for, recite in your mind all
the things you're thankful for, count
your blessings. I think everybody should
be counting their blessings all the
time. There's always something to be
thankful for. But in terms of a
scientifically grounded gratitude
practice that is also scientifically
demonstrated to shift your physiology at
the level of your immune system and your
neural circuitry, reducing anxiety,
increasing motivation, all these
wonderful things that so many of us are
chasing all the time as goals. I think a
gratitude practice reveals itself to be
an immensely powerful tool. Thank you
for your time and attention today
learning about the science of gratitude.
And last, but certainly not least, thank
you for your interest in science.
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